QSP

Animal models have long served as the preclinical gatekeeper for tuberculosis drug development, yet they systematically fail to predict human pharmacokinetics, efficacy, and toxicity—a translation gap that has left TB drug discovery inefficient, costly, and ethically burdensome. Quantitative systems pharmacology (QSP) modeling frameworks enable researchers to evaluate host-directed therapies (HDTs) against Mycobacterium tuberculosis by mechanistically […]