Mechanistic Modeling

Translational PBPK-QSP Platforms for Tuberculosis Drug Development

Leave a Comment / Mechanistic Modeling, QSP / krinaj@gmail.com

Animal models have long served as the preclinical gatekeeper for tuberculosis drug development, yet they systematically fail to predict human pharmacokinetics, efficacy, and toxicity - a translation gap that has left TB drug discovery inefficient, costly, and ethically burdensome. Quantitative systems pharmacology (QSP) modeling frameworks enable researchers to evaluate host-directed therapies (HDTs) against Mycobacterium tuberculosis by mechanistically […]

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Physiologically-Based Pharmacokinetic (PBPK) Models

Leave a Comment / Mechanistic Modeling, Pharmacokinetic Modeling / krinaj@gmail.com

PBPK is a computational approach that predicts how a drug moves through the body - how it is absorbed, distributed, metabolized, and eliminated. Unlike traditional methods that rely heavily on animal studies, PBPK models can use lab-based (in vitro) and physicochemical property data to simulate drug behavior in humans before any in vivo testing. This makes PBPK

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