Animal models have long served as the preclinical gatekeeper for tuberculosis drug development, yet they systematically fail to predict human pharmacokinetics, efficacy, and toxicity - a translation gap that has left TB drug discovery inefficient, costly, and ethically burdensome. Quantitative systems pharmacology (QSP) modeling frameworks enable researchers to evaluate host-directed therapies (HDTs) against Mycobacterium tuberculosis by mechanistically […]
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